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| Aspect | Observations / Recommendations | |--------|---------------------------------| | | Hematologic malignancies with transcriptional addiction (e.g., AML with MLL‑rearrangements, multiple myeloma) appear most promising based on in‑vitro sensitivity. | | Biomarker strategy | • Phospho‑Ser2‑RNAPII in peripheral blood mononuclear cells (PBMCs) as a pharmacodynamic marker. • Baseline MYC or MCL‑1 expression as predictive biomarkers. | | Dosing regimen | PK suggests once‑daily oral dosing at ~ 20‑30 mg kg⁻¹ (human equivalent ≈ 1.6‑2.4 mg kg⁻¹). A 3‑on/4‑off schedule could mitigate hepatic toxicity. | | Safety monitoring

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